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Tiagabine is an antiepileptic drug used for the treatment of partial seizures in humans. Recently, this drug has been found useful in several non-epileptic conditions, including anxiety, chronic pain and sleep disorders. Since tachycardia-an impairment of cardiac rhythm due to cardiac ion channel dysfunction-is one of the most commonly reported non-neurological adverse effects of this drug, in the present paper we have undertaken pharmacological and numerical studies to assess a potential cardiovascular risk associated with the use of tiagabine. A chemical interaction of tiagabine with a model of human voltage-gated ion channels (VGICs) is described using the molecular docking method. The obtained in silico results imply that the adverse effects reported so far in the clinical cardiological of tiagabine could not be directly attributed to its interactions with VGICs. This is also confirmed by the results from the isolated organ studies (i.e., calcium entry blocking properties test) and in vivo (electrocardiogram study) assays of the present research. It was found that tachycardia and other tiagabine-induced cardiac complications are not due to a direct effect of this drug on ventricular depolarization and repolarization.Įpidemiological studies have consistently shown that people with epilepsy have a higher prevalence of structural cardiac disease than those without it. The functioning of neurons, muscles and cardiac myocytes is based on action potentials (APs) generated by transmutational ion currents mediated mainly by sodium, calcium and potassium. There is some evidence, based on the effect of clinical drugs on cardiac APs, indicating the classification of cardiac ion channels into two classes.Īccording to the guidelines of the Comprehensive in vitro Proarrhythmia Assay (CiPA), a set of six ion channels has been selected for which currents are important for both the repolarization and depolarization of the cardiac action potential (AP). The first class contains the most important cardiac ion channels, such as K V11.1, Na V1.5 and Ca V1.2. The second class comprises K V4.3, K vLQT1/mink and Kir2.1 and is less critical for the assessment of all drugs under CiPA. Ī common feature of both neurological disorders (e.g., epilepsy and chronic pain) and cardiac dysrhythmias is cell (neuronal cell and cardiac myocyte, respectively) hyperexcitability. Therefore, drugs affecting cell excitability threshold within the nervous tissue can also interact with cardiac cell APs and vice versa. Having said that, the Discover DJ represents a viable platform for budding DJs to cut their teeth on without spending big bucks on professional gear like CD turntables and analog mixers.It has to be emphasized that this drug-induced effect might sometimes be harmful as it may lead to the occurrence of additional alterations in neuronal or cardiac cell reactivity, thus being a cause for additional drug-induced (iatrogenic) complications.

The only caveat we can see is the two-band equalizer, which lacks the standard mid-range equalizer of professional DJ equipment.

Unlike a vast majority of entry-level digital DJ setups, which often use an iPod or iPhone as a sound source, the Discover DJ has pitch control - meaning you can get two different tunes playing in time (known as beatmatching or beatmixing) and blend them together to create a musically coherent and unique performance. Users can browse their music library, and manipulate two digital decks and a digital mixer, all from the Discover DJ - without ever touching a mouse or keyboard.

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Discover Dj Pro Ion Discover Dj 1.2.9 Discover.

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The Discover DJ connects to a computer with USB, is bus-powered, and requires no drivers - although you will need to install the bundled DJ software, MixVibes CROSS LE to get started. Mixvibes Cross 1.5.0 crack: Mixvibes Cross 1 1 0 serial number maker: Mixvibes Pro V 5 02 key generator.

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Today at IFA 2009, we came across ION Audio's Discover DJ controller, a USD$99 product which turns any PC or Mac into a digital DJ setup.

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Just this year, we've seen software that teaches you to play guitar, drums and the piano (and you can check our music category for much more).

The democratization of music is something Gizmag has been watching for some time.

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